Coronary vessel development
Vertebrate organ development and regeneration requires the establishment of a blood vessel network that supports each tissue’s physiological needs. The blood vasculature contains diverse cell types organized into a stereotyped vessel hierarchy that ensures efficient transport of blood and oxygen. In addition, each organ’s vascular bed develops tissue-specific characteristics that are required for optimal function. Vascular development in many organs can be broadly divided into two steps: 1. Sprouting angiogenesis to create an immature vascular plexus and 2. Plexus remodeling to form arteries, capillaries, and veins. However, many questions remain about how organ-specific vascular beds are constructed, such as what is the identity of inductive factors produced by target tissues and paracrine factors produced by the vessel cells themselves as well as how mechanical forces imparted by blood flow influence the developmental process.