Red-Horse Lab

About Us


We use cardiovascular development as a model to study the signals that instruct cell fate and guide morphogenesis during organ formation in the mammalian embryo. Our current focus is to fate-map the different cellular sources that give rise to the coronary arteries of the heart and to identify the molecules that direct their migration and differentiation. Our long-term goal is to use this information to better understand and treat cardiovascular diseases.

 

Recent News


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Research

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Coronary vessel development

Vertebrate organ development and regeneration requires the establishment of a blood vessel network that supports each tissue’s physiological needs. The blood vasculature contains diverse cell types organized into a stereotyped vessel hierarchy that ensures efficient transport of blood and oxygen. In addition, each organ’s vascular bed develops tissue-specific characteristics that are required for optimal function. Vascular development in many organs can be broadly divided into two steps: 1. Sprouting angiogenesis to create an immature vascular plexus and 2. Plexus remodeling to form arteries, capillaries, and veins. However, many questions remain about how organ-specific vascular beds are constructed, such as what is the identity of inductive factors produced by target tissues and paracrine factors produced by the vessel cells themselves as well as how mechanical forces imparted by blood flow influence the developmental process.

Our Team

 
 
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