Dani K., Jeff N., and Kristy provide commentary on a scalable 3D vascular organoid differentiation protocol by Gong et al. in their recently published Cell Stem Cell Preview, “Vascular organoids get a speed boost for regenerative repair.” This exciting piece highlights advances in the field of vascular organoid generation where the reviewed protocol “enables control of iEC and iMC ratios and allows specification of arterial or venous endothelial subtype fates within complex organoids.” Their work underscores how this optimized system could transform efforts in disease modeling and therapeutic repair.
Congratulations on the accomplishment and for contributing clear perspective on an important and rapidly evolving area of stem cell research!
For the full text, visit: Cell Stem Cell
Figure 1. Schematic of engineered vascular organoids and applications
Generation of VOs from human iPSCs via independent activation of ETV2 (iECs) and NKX3.1 (iMCs)